2014 Fiscal Year Final Research Report
The role of protein glycosylation in the regulation of Ephrin/Eph signal
| Project/Area Number |
23687032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
CHIHARA Takahiro 東京大学, 薬学研究科(研究院), 准教授 (00431891)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | Eph / Ephrin / 神経 / 発生 / 糖鎖修飾 |
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| Outline of Final Research Achievements |
An evolutionarily conserved signal, Ephrin/Eph signal functions in axon guidance, blood vessel formation and body segmentation etc. In this study, we aimed to reveal the regulatory mechanism of Ephrin/Eph signal by using biochemical methods and Drosophila genetics. We succeeded to show the significance of Ephrin N-glycosylation for its stability and subcellular localization, which is essential for proper Ephrin/Eph signal in neural development.
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| Free Research Field |
神経発生遺伝学
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