2013 Fiscal Year Final Research Report
Identification of Novel Intracellular Signal Transduction Pathways Activated by AdipoR1 in the skeletal muscle and the liver
| Project/Area Number |
23689048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWABU Masato 東京大学, 医学部附属病院, 特任助教 (30557236)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 代謝学 / メタボリックシンドローム / アディポネクチン / アディポネクチン受容体 |
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| Research Abstract |
Plasma adiponectin levels are reduced in obesity, which causes insulin resistance and type 2 diabetes. In skeletal muscle, AdipoR1 is predominantly expressed and activates AMPK and PPARgamma coactivator (PGC)-1alpha as well as calcium signalling pathways, which have also been shown to be activated by exercise. So, we proposed to identify the novel intracellular signal transduction pathways activated by AdipoR1 in the skeletal muscle and the liver.
We have elucidated the physiological and pathophysiological roles of adiponectin/AdipoR1 in the liver. Moreover, we identified the candidate key molecules relevant to exercise and AdipoR1 signaling pathways in the skeletal muscle, and clarified the gluconeogenesis mechanism regulated by AdipoR1 in the liver.
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Research Products
(40 results)
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[Journal Article] A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity2013
Author(s)
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S and Kadowaki T
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Journal Title
Nature
Volume: 503
Pages: 493-498
DOI
Peer Reviewed
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[Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y and Kadowaki T. A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012
Author(s)
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Iwata M, Hirose H, Kaku K, Ito C, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Kasuga M, Kamatani N
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Journal Title
Hum Mol Genet
Volume: 21
Pages: 3042-2049
DOI
Peer Reviewed
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[Journal Article] Global Mapping of Cell Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation2011
Author(s)
Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H and Kadowaki T
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Journal Title
PLoS Genet
Volume: 7
Pages: e1002311
DOI
Peer Reviewed
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[Journal Article] Crystal structure of the CA^2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-6092011
Author(s)
Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y and Yokoyama S
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 22570-22579
DOI
Peer Reviewed
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[Journal Article] Structural basis for compound C inhibition of the human AMP-activated protein kinaseα2 subunit kinase domain2011
Author(s)
Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y and Yokoyama S
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Journal Title
Acta Crystallogr D BiolCrystallogr
Volume: 67
Pages: 480-487
DOI
Peer Reviewed
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[Presentation] Adiponectin/AdipoR1 Regulate PGC-1alpha and Mitochondria by Ca and AMPK/SIRT1 in Skeletal Muscle, Leading to Amelioration of Obese Diabetes, Like Exercise2011
Author(s)
MASATO IWABU, TOSHIMASA YAMAUCHI, MIKI IWABU, NAOTO KUBOTA, KOHJIRO UEKI, TAKASHI KADOWAKI
Organizer
American Diabetes Association, 71st Scientific Sessions
Place of Presentation
SAN DIEGO, CA, USA
Year and Date
2011-06-25
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