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2012 Fiscal Year Final Research Report

Reconfigurable on-chip molecular analysis using DNA operationsin micro-droplets

Research Project

  • PDF
Project/Area Number 23700362
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionOsaka University

Principal Investigator

OGURA Yusuke  大阪大学, 大学院・情報科学研究科, 准教授 (20346191)

Project Period (FY) 2011 – 2012
KeywordsDNAコンピュータ / 光ピンセット / 生体生命情報学 / システムオンチップ / 情報システム
Research Abstract

We studied on-chip molecular analysis in which a processing procedure can be configured dynamically. Two logic operation systems were investigated for easy analysis of DNA information. A method for identifying liquid-based microreactors was constructed using fluorescence color encoding. We demonstrated local and selective induction of DNA reactions by optical manipulation of liquid-based microreactors, and execution of DNA logic operations inside the microreactors.

  • Research Products

    (24 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (17 results)

  • [Journal Article] Fluorescence resonance energy transfer-based molecular logic circuit using a DNA scaffold2012

    • Author(s)
      Takahiro Nishimura, Yusuke Ogura, and Jun Tanida
    • Journal Title

      Appl. Phys. Lett.

      Volume: Vol. 101 Pages: 233703

    • DOI

      DOI:10.1063/1.4769812

    • Peer Reviewed
  • [Journal Article] Optofluidic DNA computation based on optically manipulated microdroplets2012

    • Author(s)
      Takahiro Nishimura, Yusuke Ogura, and Jun Tanida
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: Vol. 12

    • DOI

      DOI:10.1007/s10404-012-0934-6.

    • Peer Reviewed
  • [Journal Article] フォトニックDNAナノマシン2012

    • Author(s)
      小倉裕介,西村隆宏,谷田 純
    • Journal Title

      光学

      Volume: Vol. 41 Pages: 90-92

  • [Journal Article] Photonic Nanoscale Automaton Based On Photo-/Heat-Regulated DNA Displacement Reactions2012

    • Author(s)
      Hiroto Sakai, Yusuke Ogura, and Jun Tanida
    • Journal Title

      International Journal of Unconventional Computing

      Volume: Vol.8 Pages: 207-220

    • Peer Reviewed
  • [Journal Article] Large-area manipulation of microdroplets by holographic optical tweezers based on a hybrid diffractive system2011

    • Author(s)
      Yusuke Ogura, Yuki Kazayama, Takahiro Nishimura and Jun Tanida
    • Journal Title

      Applied Optics

      Volume: Vol. 50 Pages: H36-H41

    • DOI

      DOI:10.1364/AO.50.000H36.

    • Peer Reviewed
  • [Journal Article] Spatially parallel control of DNA reactions in optically manipulated micro-droplets2011

    • Author(s)
      Yusuke Ogura, Takahiro Nishimura, and Jun Tanida
    • Journal Title

      Journal of Nanophotonics

      Volume: Vol. 5 Pages: 051702

    • DOI

      DOI:10.1117/1.3574171

    • Peer Reviewed
  • [Journal Article] DNAコンピューティングの原理と展開2011

    • Author(s)
      倉裕介
    • Journal Title

      生産と技術

      Volume: Vol. 63 Pages: 28-33

  • [Presentation] Optical Manipulation of Liquid-based Microreactors in Optofluidic DNA Computation2013

    • Author(s)
      Takahiro Nishimura, Yuki Kazayama, Yusuke Ogura, and Jun Tanida
    • Organizer
      in Optical trapping applications
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2013-04-17
  • [Presentation] リポソーム内DNA論理演算の実証2013

    • Author(s)
      風山祐輝,小倉裕介,谷田純
    • Organizer
      第60回応用物理学会春期学術講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2013-03-29
  • [Presentation] 光プログラム可能なDNA論理演算法2013

    • Author(s)
      小倉裕介,浅川洋平,西村隆宏,谷田 純
    • Organizer
      レーザ学会学術講演会第33回年次大会
    • Place of Presentation
      姫路商工会議所
    • Year and Date
      2013-01-30
  • [Presentation] Photonic Nanoscale Logic Using Fluorescence Resonance Energy Transfer on a DNA Scaffold2012

    • Author(s)
      Yusuke Ogura, Takahiro Nishimura, Hirotsugu Yamamoto, Kenji Yamada, Jun Tanida
    • Organizer
      in the Second Japan-Korea Workshop on Digital Holography and Information Photonics
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2012-11-19
  • [Presentation] 蛍光カラー符号化に基づく液体マイクロリア図4 リポソームの融合手順. クターの識別法2012

    • Author(s)
      風山祐輝, 小倉裕介, 谷田 純
    • Organizer
      日本光学会年次学術講演会 Optics & Photonics Japan 2012
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2012-10-24
  • [Presentation] Functional molecular sensing using photonic DNA nano-processor2012

    • Author(s)
      Yusuke Ogura, Takahiro Nishimura, Hirotsugu Yamamoto, Kenji Yamada, Jun Tanida
    • Organizer
      in the 1st International Workshop on Information Physics and Computing in Nano-scale Photonics and Materials
    • Place of Presentation
      Orleans, France
    • Year and Date
      2012-09-07
  • [Presentation] 蛍光共鳴エネルギー移動を利用した分子入力・光出力論理回路の実装2012

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田 純
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-16
  • [Presentation] 光ピンセットを用いた液体マイクロリアクターのインタラクティブ制御2012

    • Author(s)
      風山祐輝, 小倉裕介, 鈴木宏明, 谷田純
    • Organizer
      レーザー学会学術講演会第32回年次大会
    • Place of Presentation
      TKP仙台カンファレンスセンター
    • Year and Date
      2012-02-01
  • [Presentation] 蛍光共鳴エネルギー移動を利用したスキャフォールドDNA論理演算2011

    • Author(s)
      西村隆宏, 小倉裕介, 山田憲嗣, 山本裕紹, 谷田 純
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
  • [Presentation] 光とDNAの協調によるナノ情報処理2011

    • Author(s)
      小倉裕介, 西村隆宏, 酒井寛人, 山本裕紹, 山田憲嗣, 谷田 純
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
  • [Presentation] Photonic DNA Processor: A Computing DNA-Nanomachine with Sensing and Acting Functions2011

    • Author(s)
      Yusuke Ogura
    • Organizer
      in BIT's 1st Annual World Congress of Nano-S&T
    • Place of Presentation
      Dalian, China
    • Year and Date
      2011-10-25
  • [Presentation] Bio-molecular sensing by use of DNA that can be activated and reset via photonic signals2011

    • Author(s)
      西村隆宏, 小倉裕介, 山本裕紹, 山田憲嗣, 谷田 純
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学
    • Year and Date
      2011-09-18
  • [Presentation] DNA配列置換反応を用いた光入力型DNAオートマトンの実装モデル2011

    • Author(s)
      酒井寛人, 小倉裕介, 谷田 純
    • Organizer
      2011年度秋季第72回応用物理学会学術講演会
    • Place of Presentation
      山形大学
    • Year and Date
      2011-08-31
  • [Presentation] A photonic DNA processor: concept and implementation2011

    • Author(s)
      Takahiro. Nishimura, Yusuke Ogura, Kenji Yamada, Hirotsugu Yamamoto, and Jun Tanida
    • Organizer
      SPIE Optics & Photonics 2011
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-08-23
  • [Presentation] Optical Manipulation of Microdroplets by Use of a Spatial Light Modulator and a Static Computer Generated Hologram2011

    • Author(s)
      Yusuke Ogura, Yuki Kazayama, Takahiro Nishimura, Jun Tanida
    • Organizer
      in Information Photonics 2011
    • Place of Presentation
      Ottawa, Canada
    • Year and Date
      2011-05-19
  • [Presentation] Evaluation of holographic optical tweezers based on a hybrid diffractive system for manipulating microdroplets2011

    • Author(s)
      Yuki Kazayama, Takahiro Nishimura, Yusuke Ogura, Jun Tanida
    • Organizer
      in Digital Holography and Three-Dimensional Imaging 2011
    • Place of Presentation
      University of Tokyo, Japan
    • Year and Date
      2011-05-11
  • [Presentation] Prototype demonstration of a photonic DNA processor: a photonically-controlled DNA nanomachine of sensing, computing, and actuating2011

    • Author(s)
      Takahiro Nishimura, Yusuke Ogura, Kenji Yamada, Hirotsugu Yamamoto, and Jun Tanida
    • Organizer
      in 8th Annual Conference on Foundations of Nanoscience
    • Place of Presentation
      Snowbird, USA
    • Year and Date
      2011-04-14

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Published: 2014-09-25  

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