Slitrk5 knock-out mice showed elevated anxiety and depression like behavior.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700457
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MATSUMOTO Yoshifumi 独立行政法人理化学研究所, 行動発達障害研究チーム, 研究員 (60513463)
• Project Period (FY): 2011 – 2012
• Keywords: SLITRK / 不安障害 / 気分障害

Research Abstract

Slitrk family is strongly associated with the psychiatric disorder or auditory function. However, Slitrk5 function has not been known yet. We therefor generated Slitrk5 knockout (KO) mouse and performed comprehensive behavioral tests. Slitrk5 KO mice showed the increased anxiety and depression like behavior, and moreover showed significantly decreased serotonin levels in hippocampus among various brain regions. Taken together with these results, Slitrk5 is strongly associated with pathogenesis of anxiety and depression disorder through impairment of serotonin concentration in hippocampus.

Research Products

• [Journal Article] 3 SLITRK6 mutations cause myopia and deafness in humans and mice (2013)
  • Author(s): Mustafa Tekin, Barry A. Chioza, Yoshifumi Matsumoto, Oscar Diaz-Horta, Harold E. Cross, Duygu Duman, Haris Kokotas, Heather L. Moore-Barton, Kazuto Sakoori, Maya Ota, Yuri S. Odaka, Joseph Foster II, F. Basak Cengiz, Suna Tokgoz-Yilmaz, Oya Tekeli, Maria Grigoriadou, Michael B. Petersen, Ajith Sreekantan-Nair, Kay Gurtz, Xia-Juan Xia, Arti Pandya, Michael A. Patton, Juan. Young, Jun Aruga, and Andrew H. Crosby
  • Journal Title: The Journal of Clinical Investigation 2013 Volume: Volume 123 Number 5 Pages: 2094-102
  • Peer Reviewed
• [Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTP・trans-synaptic interaction (2012)
  • Author(s): Takahashi H., Katayama K., Sohya K., Miyamoto H., Prasad T., Matsumoto Y., Ota M., Yasuda H., Tsumoto T., Aruga J and Craig AM
  • Journal Title: Nat Neurosci Volume: 15(3) Pages: 389-98
  • Peer Reviewed
• [Journal Article] LRR シナプスオーガナイザーと神経疾患 (2012)
  • Author(s): 有賀純、松本圭史
  • Journal Title: in vivo実験医学によるヒト疾患解明の最前線 Volume: vol. 30 No2 Pages: 218-223
• [Journal Article] Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice (2011)
  • Author(s): Matsumoto Y., Katayama K., Okamoto T., Yamada K., Takashima N., Nagao S., Aruga J.
  • Journal Title: PLoS One Volume: 26 ; 6(1) Pages: e16497
  • Peer Reviewed
• [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN (2011)
  • Author(s): Matsumoto Y., Takashima N., Nozaki Y., Nishioka N., Kudoh M., Aruga J
  • Organizer: Society for Neuroscience meeting 2011
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 20111112-16
• [Presentation] Slitrk6 欠損マウスの聴覚および前庭機能異常について (2011)
  • Author(s): 松本圭史、片山圭一、岡本武人、山田一之、永雄総一、工藤雅治、 有賀純
  • Organizer: 第34回日本神経科学大会、パシフィコ横浜
  • Place of Presentation: 横浜
  • Year and Date: 20110914-17
• [Remarks] 理化学研究所・脳科学総合研究センター・行動発達障害研究チーム
  • URL: http://lcn.brain.riken.jp/topicsj.html