2013 Fiscal Year Final Research Report
Visualization of Mechanical Response of Molecular Machines working in vivo
| Project/Area Number |
23710144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子モーター / 分子機械 / 高圧力顕微鏡 / 水和 / べん毛モーター / １分子計測 / バイオイメージング |
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| Research Abstract |
In this research project, we developed a new assay that enables to control the functional expression of molecular machines working in living cells. We constructed a new high-pressure microscope that allows us to modulate the intermolecular interactions between protein and water molecules. By using this system, we were successful to change the rotational direction of Escherichia coli flagellar motors.
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