Design and Evaluation of Stable Hydrophilic Fullerene C60 Nanoparticlesas Next Generation Photoserlsitizer in Photodyrlamic Therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790062
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Sojo University
• Principal Investigator: IOHARA Daisuke 崇城大学, 薬学部, 助手 (40454954)
• Project Period (FY): 2011 – 2012
• Keywords: フラーレン / シクロデキストリン / がん光線力学療法 / 活性酸素種 / ナノ粒子 / 光増感剤

Research Abstract

Fullerene C60 has been appealing as an efficient photosensitizer in photodynamictherapy.The objective of this study is to prepare C60 nanoparticles via 2-hydroxypropy1一β一cyclodextrin,which is clinically used as a safe solubilizing agent for several preparations.We elucidated its nanostructure,physical properties and biological activities.

Research Products

• [Journal Article] Evaluation of Photodynamic Activity of C60/2-Hydroxypropyl一β一cyclodextrin Nanoparticles (2012)
  • Author(s): D.Iohara,M.Hiratsuka,F.Hirayama,K.Takeshita,K.Motoyama,H.Arimaand K,Uekama
  • Journal Title: J,Pharm,Sci Volume: Vol.101 Pages: 3390-3397
  • DOI: DOI:10.1002/jps.23045
  • Peer Reviewed
• [Journal Article] Formation of Stable Hydrophilic C60 Nanoparticlesby2-Hydroxypropy1一β一cyclodextrin (2011)
  • Author(s): D,Iohara,F.Hirayama,K.Higashi,K.Yamamoto and K.Uekama
  • Journal Title: Mol.Pharmaceut Volume: Vol.8 Pages: 1276-1284
  • DOI: DOI:10.1021/mp200204v
  • Peer Reviewed
• [Presentation] 親水性シクロデキストリンを用いた水酸化フラーレンのナノ粒子化と物性評価 (2012)
  • Author(s): 梅崎至高、庵原大輔、安楽誠、上釜兼人、平山文俊
  • Organizer: 第29回シクロデキストリンシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20120906-07
• [Presentation] Preparation of Hydrophilic C60 Nanoparticlesby2-Hydroxypropy1一β一cyclodextrin and It's ApPIication to Photodynamic Therapy (2012)
  • Author(s): D.lohara,F.Hirayama,M.AnrakuandK.Uekama
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin,China
  • Year and Date: 20120506-10
• [Presentation] 親水性C60/2一ヒドロキシプロピルーβ一シクロデキストリンナノ粒子の構造と光線力学活性の評価 (2012)
  • Author(s): 庵原大輔、平山文俊,東顕二郎、安楽誠、山本恵司、上釜兼人
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道
  • Year and Date: 20120328-31
• [Presentation] C60/2一ヒドロキシプロピルーβ一シクロデキストリンナノ粒子の調製と光線力学活性の評価 (2011)
  • Author(s): 庵原大輔、平山文俊、東顕二郎、安楽誠、山本恵司、上釜兼人
  • Organizer: 第28回シクロデキストリンジンポジウム
  • Place of Presentation: 秋田
  • Year and Date: 20110908-09
• [Remarks]
  • URL: http://www.ph.sojo-u.ac.jp/Ndio/index.htm