2012 Fiscal Year Final Research Report
Roles of SYD-1 and SYD-2 proteins and neuronal trafficking in presynaptic formation
| Project/Area Number |
23790070
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TARU Hidenori 北海道大学, 創成研究機構, 特任助教 (30533731)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 神経生物学 |
|---|
| Research Abstract |
Neuronal synapses are cell adhesion structures, which are fundamental units for functions of neuronal system. In nematode C.elegans, SYD (SYnapse Defective) -1 and SYD-2 have been identified as central regulators of presynaptic formation. Based on a large scale modifier screen and genetic analysis, we proposed a possibility that presynaptic components are precisely assembled by SYD-1/SYD-2 pathway under negative regulation involving a cadherin-like cell-adhesion molecule.
|
Research Products
(8 results)
