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2012 Fiscal Year Final Research Report

Roles of SYD-1 and SYD-2 proteins and neuronal trafficking in presynaptic formation

Research Project

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Project/Area Number 23790070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

TARU Hidenori  北海道大学, 創成研究機構, 特任助教 (30533731)

Project Period (FY) 2011 – 2012
Keywords神経生物学
Research Abstract

Neuronal synapses are cell adhesion structures, which are fundamental units for functions of neuronal system. In nematode C.elegans, SYD (SYnapse Defective) -1 and SYD-2 have been identified as central regulators of presynaptic formation. Based on a large scale modifier screen and genetic analysis, we proposed a possibility that presynaptic components are precisely assembled by SYD-1/SYD-2 pathway under negative regulation involving a cadherin-like cell-adhesion molecule.

  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Cleavage of Alcadeins by γ-secretase at the γ-site is determined by a mechanism2013

    • Author(s)
      Yi Piao, Satomi Urano, Ayano Kimura,Yuhki Saito, Hidenori Taru, Saori Hata and Toshiharu Suzuki
    • Journal Title

      PLoS One 8

      Pages: e62431

    • DOI

      doi:10.1371/journal.pone.0062431

    • Peer Reviewed
  • [Journal Article] The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly2011

    • Author(s)
      Hidenori Taru and Yishi Jin
    • Journal Title

      J. Neuroscience

      Volume: 31 Pages: 16261-16268

    • DOI

      doi:10.1523/JNEUROSCI.0002-11.2011

    • Peer Reviewed
  • [Journal Article] Intracellular trafficking of the amyloid beta-protein precursor (APP) regulated by novel function of X11-like2011

    • Author(s)
      Yuhki Saito, Mayu Akiyama, Yoichi Araki, Akio Sumioka, Maki Shiono, Hidenori Taru, Tadashi Nakaya, Tohru Yamamoto, and Toshiharu Suzuki
    • Journal Title

      PLoS One 6

      Pages: e22108

    • DOI

      doi:10.1371/journal.pone.0022108

    • Peer Reviewed
  • [Presentation] Identification of a cell adhesion molecule involved in negative regulation of presynaptic assembly in C.elegans2013

    • Author(s)
      Hidenori Taru
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      ボストン国際会議場(USA)
    • Year and Date
      2013-04-22
  • [Presentation] 線虫(C.elegans)DDニューロンのプレシナプス除去に関わる遺伝子の探索2012

    • Author(s)
      星野裕子、多留偉功
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-15
  • [Presentation] Identification of mutants involved in SYD-1-mediated presynaptic assembly in C.elegans2012

    • Author(s)
      Hidenori Taru
    • Organizer
      8th FENS Forum of Neuroscience
    • Place of Presentation
      バルセロナ国際会議場(スペイン)
    • Year and Date
      2012-07-15
  • [Presentation] The Liprin Homology Domain is Essential for the Homomeric Interaction of SYD-2/Liprin-alpha Protein in Presynaptic Assembly2011

    • Author(s)
      Hidenori Taru and Yishi Jin
    • Organizer
      The American Society for Cell Biology, Annual Meeting
    • Place of Presentation
      デンバー国際会議場(USA)
    • Year and Date
      2011-12-04
  • [Remarks]

    • URL

      http://www.cris.hokudai.ac.jp/taru/

URL: 

Published: 2014-09-25  

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