2012 Fiscal Year Final Research Report
Molecular Mechanism of fatty liver in Nrf1 knockout mice
| Project/Area Number |
23790351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KATSUOKA Fumiki 東北大学, 東北メディカル・メガバンク機構, 准教授 (30447255)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写因子 / 脂質代謝 / 脂肪肝炎 / Nrf1 |
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| Research Abstract |
Through the analyses of Nrf1 liver-specific knockout mice, we examined the function of Nrf1 in the livers. Gene expression analysis using microarray, chromatin immunoprecipitation analysis, and metabolome analysis using CE-TOFMS revealed that Nrf1 directly and indirectly regulates the genes related to amino acid and lipid catabolism, suggesting that the dysregulation of these metabolic genes is associated with liver phenotypes of Nrf1 knockout mice.
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