2012 Fiscal Year Final Research Report
Analysis of molecular mechanism of tumor progression induced by an alpha6beta4 integrin
| Project/Area Number |
23790373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | β4インテグリン / 癌 / 糖鎖 |
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| Research Abstract |
In this study, to elucidate the role of N-glycosylation on β4 integrin, we established the keratinocytes re-expressing wild-type or N-glycosylation-defective β4 integrin in β4 integrin null keratinocytes. The analysis using the keratinocytes indicated that N-glycosylation plays important roles for integrin-mediated cell adhesion and migration. In addition, we found that β4 integrin forms supramolecular complex with EGFR through cross-linking with galectin-3-mediated N-glycans, thereby promoting cellular signaling and the following cellular function.
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Research Products
(7 results)
