2012 Fiscal Year Final Research Report
The role of resistin-like molecules in natural immune system involving insulin resistance.
| Project/Area Number |
23791047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The Institute for Adult Diseases Asahi Life Foundation |
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Principal Investigator |
KUSHIYAMA Akifumi 公益財団法人朝日生命成人病研究所, その他部局等, 准教授 (30435820)
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Tomoichiro 広島大学, 医歯(薬)学総合研究科, 教授 (70242063)
SAKODA Hideyuki 東京大学, 医学部附属病院, 特任講師 (50376464)
KURIHARA Hiroki 東京大学, 医学系研究科, 教授 (20221947)
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| Project Period (FY) |
2011 – 2012
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| Keywords | インスリン抵抗性 / メタボリックシンドローム / NASH モデル |
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| Research Abstract |
Resistin-like molecule (RELM) β, secretory protein homologous to resistin, reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of RELMβ in the insulin resistance. In RELMβ KO mice, insulin resistance is ameliorated, and lipid accumulation, inflammation, and fibrosis in liver is ameliorated in NASH model, compared with control mice. Furthermore, ELISA system measuring RELMβ is developed, and now investigating RELMβexpression accompanied with change of dietary habitat.
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[Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S,Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T
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Journal Title
Arterioscler Thromb Vasc Biol
DOI
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[Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice2013
Author(s)
Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T
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Journal Title
Adipocyte
Volume: 2(1)
Pages: 28-32
DOI
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[Journal Article] Integrator complex plays an essential role in adipose differentiation2013
Author(s)
Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T
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Journal Title
Biochem Biophys Res Commun
Volume: 434(2)
Pages: 197-202
DOI
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[Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuch T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 287(53)
Pages: 44526-35
DOI
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[Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32(2)
Pages: 291-8
DOI
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[Journal Article] Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling2012
Author(s)
Arima Y, Miyagawa-Tomita S, Maeda K, Asai R, Seya D, Minoux M, Rijli FM, Nishiyama K, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H.
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Journal Title
Nat Commun
Volume: 3
Pages: 1267
DOI
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302(3)
Pages: E286-96
DOI
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[Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications2012
Author(s)
Nakarai H, Yamashita A, Nagayasu S, Iwashita M, Kumamoto S, Ohyama H, Hata M, Soga Y, Kushiyama A, Asano T, Abiko Y, Nishimura F
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Journal Title
Innate Immun
Volume: 18(1)
Pages: 164-70
DOI
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[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.2011
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T.
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Journal Title
J Biol Chem
Volume: 286(23)
Pages: 20812-22
DOI
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[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
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Journal Title
Am J Physiol Cell Physiol
Volume: 300(5)
Pages: C1047-54
DOI
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