Development of analysis tools for epidermal gdT cells, and its functional analysis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: SHIMURA ERI 順天堂大学, 医学(系)研究科(研究院), 研究員 (30586342)
• Research Collaborator: NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409) ; SUDO Katsuko 東京医科大学, 医学部, 講師 (50126091) ; SUTO Hajime 順天堂大学, 医学部, 准教授 (90286740)
• Project Period (FY): 2011 – 2013
• Keywords: 表皮gdT細胞 / 皮膚免疫 / 接触性皮膚炎 / gdT細胞 / アレルギー

Research Abstract

Previous studies suggested that DETCs (dendritic epidermal T cells) which present in the epidermis of mouse skin plays an important role in skin diseases such as wound healing, skin cancer and contact hypersensitivity. However, the precise role of DETCs in these skin diseases is poorly understood.
We searched for candidate genes that expressed DETCs-specific manner, aiming to establish of an analysis tool that is specialized in the detection of DETCs and to elucidate the function of DETCs. On the other hand, we attempted to elucidate the function of DETCs in contact hypersensitivity.

Research Products

• [Journal Article] Th17 cell-derived IL-17 is dispensable for B cell antibody production (2012)
  • Author(s): Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S
  • Journal Title: Cytokine Volume: 59(1) Pages: 108-14
  • DOI: 10.1016/j.cyto.2012.03.018
  • Peer Reviewed
• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma (2012)
  • Author(s): Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S
  • Journal Title: Journal of Immunology Volume: 189(7) Pages: 3642-52
  • URL: http://www.jimmunol.org/content/189/7/3641.long
  • Peer Reviewed
• [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion (2011)
  • Author(s): Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP
  • Journal Title: circulation Volume: 124 Pages: S187-S196
  • DOI: 10.1161/CIRCULATIONAHA.110.014852
  • Peer Reviewed
• [Journal Article] Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation (2011)
  • Author(s): Shibui A, Nambu A, Shimura E, Yamaguchi S, Shiraishi C, Sato Y, Okumura K, Sugano S, Hozumi N, Nakae S
  • Volume: 60
  • Pages: 345-54
  • DOI: 10.2332/allergolint.10-OA-0283
  • Peer Reviewed
• [Presentation] Regulation of contact hypersensitivity by interleukin-21 (2013)
  • Author(s): SHIMURA Eri
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2013-12-13
• [Presentation] Regulatory roles of IL-21 receptor in contact hypersensitivity (2012)
  • Author(s): SHIMURA Eri
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場、神戸国際展示場、神戸ポートピアホテル
  • Year and Date: 2012-12-05
• [Presentation] The role of IL-21 receptor in contact hypersensitivity (2011)
  • Author(s): SHIMURA Eri
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Book] Role of IL-17 in contact hypersensitivity, J Environ Dermatol Cutan Allergol (2012)
  • Author(s): Eri SHIMURA, Susumu Nakae
  • Total Pages: 417-426
• [Book] アレルギーの臨床 (2011)
  • Author(s): 志村絵理・中江進
  • Total Pages: 22-27
  • Publisher: 北隆館