2013 Fiscal Year Final Research Report

Analyses of mechanism of the elevation of serum reactive oxidative metabolite level and expressions of related genes in an irradiated rat model

Research Project

Project/Area Number	23791389
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	National Institute of Radiological Sciences (2012-2013) Yamagata University (2011)
Principal Investigator	NOMIYA Takuma 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 医長 (60436201)
Research Collaborator	NEMOTO Kenji 山形大学, 医学部医学系研究科, 教授 KANEKO Takashi 山形大学, 医学部医学科 GOTO Jun 山形大学, 医学部医学科
Project Period (FY)	2011 – 2013
Keywords	放射線治療生物学
Research Abstract	Recently, oxidative metabolites have been able to be measured by simple small device. Radiation used in radiotherapy causes free radicals and oxidative metabolites, and irradiation causes dermatitis and sometimes causes skin ulcer in the irradiated site. We analyzed the relationships among the value of oxidative metabolites and skin reactions and gene expressions. As a result, a significant correlation was seen between the value of oxidative metabolites and irradiation dose. And some genes (e.g. NOS2, NCF1, NCF2, etc.) were overexpressed after the irradiation. It was suggested that measuring the level of serum oxidative metabolites seems to be useful for estimating degree of skin reaction, and a part of reactions to the irradiation was revealed in the gene expression level.