2012 Fiscal Year Final Research Report
In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's disease
| Project/Area Number |
23791469
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NAGAI Yuji 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20415409)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 核医学(PETを含む) |
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| Research Abstract |
A monkey was developed very severe motor dysfunction after treatment of MPTP (1 mg/kg). In this state, dopamine transporter binding in the striatum measured by PET was reduced to about 5% of MPTP pretreatment level. Although it became difficult to assess the executive function, it was suggested the need to make a prior assessment of individual sensitivity to MPTP or consider the development of PD model using repetitive treatment of lower doses of MPTP.
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