2013 Fiscal Year Final Research Report
Identifying challenges to discover cancer stem-like cells in osteosarcoma
| Project/Area Number |
23791629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Yasuhiko 金沢大学, 医学系, 准教授 (20313637)
MUNESUE Seiichi 金沢大学, 医学系, 助教 (10399040)
HARASHIMA Ai 金沢大学, 脳・肝インターフェースメディシン研究センター, 助教 (50705522)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨・軟部腫瘍学 |
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| Research Abstract |
Induced expression of RAGE (receptor for advanced glycation end-products) resulted in the co-expression of CD133 and CD24, stem-cell markers, in human osteosarcoma cell lines. Moreover, the RAGE-overexpressing cells showed higher spheroid-forming ability and a resistance to treatment of cisplatin, an anti-cancer drug, in vitro.Upregulated gene expression of cell-cycle and cell-division drivers was observed in microarray analyses . We also found that the expression of CD133 was significantly correlated with poor prognosis in patients with osteosarcoma using immunohistochemical analyses. Our results suggest that the RAGE could elicit the expression of cancer stem cell markers and may promote the cancer stem-like cell characteristics in osteosarcoma.
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Research Products
(21 results)
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[Journal Article] Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft2013
Author(s)
Miwa S, Takeuchi A, Ikeda H, Shirai T, Yamamoto N, Nishida H, Hayashi K, Tanzawa Y, Kimura H, Igarashi K, Tsuchiya H
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Journal Title
PLoS One
Volume: 8
Pages: e71362
DOI
Peer Reviewed
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[Journal Article] Prognostic value of radiological response to chemotherapy in patients with osteosarcoma2013
Author(s)
Miwa S, Takeuchi A, Shirai T, Taki J, Yamamoto N, Nishida H, Hayashi K, Tanzawa Y, Kimura H, Igarashi K, Ooi A, Tsuchiya H
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Journal Title
PLoS One
Volume: 8
Pages: e70015
DOI
Peer Reviewed
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[Journal Article] A novel combined radiological method for evaluation of the response to chemotherapy for primary bone sarcoma2012
Author(s)
Miwa S, Taki J, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Kimura H, Takeuchi A, Igarashi K, Ooi A, Tsuchiya H
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Journal Title
J Surg Oncol
Volume: 106
Pages: 273-9
DOI
Peer Reviewed
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[Journal Article] Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways2012
Author(s)
Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H
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Journal Title
Anticancer Res
Volume: 32
Pages: 3643-9
URL
Peer Reviewed
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[Journal Article] TNF-αand tumor lysate promote the maturation of dendritic cells for immunotherapy for advanced malignant bone and soft tissue tumors2012
Author(s)
Miwa S, Nishida H, Tanzawa Y, Takata M, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Kimura H, Igarashi K, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
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Journal Title
PLoS One
Volume: 7
Pages: e52926
DOI
Peer Reviewed
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[Presentation] 骨肉腫に対するカフェイン併用化学療法と縮小手術の中長期成績2013
Author(s)
武内章彦,山本憲男,白井寿治,西田英司,林克洋,丹沢義一,木村浩明,五十嵐健太郎,稲谷弘幸,下崎真吾,加藤貴士,青木裕,土屋弘行
Organizer
第51回日本癌治療学会学術集会
Place of Presentation
国立京都国際会館
Year and Date
20131024-26
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