2012 Fiscal Year Final Research Report
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation
| Project/Area Number |
23791679
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 変形性関節症 / ヒアルロン酸 / CD44 / 断片化 / Lipid Raft / Statin製剤 |
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| Research Abstract |
We demonstrated that simvastatin effectively inhibited the IL-1/OSM induced CD44 cleavage. This inhibitory effect would mainly depend on the suppressive cholesterol production, the major component of lipid raft. However, our current results also suggest that the Ras and Rac/Rho pathway were included in the mechanism of the suppressive CD44 cleavage. The interactional expression of membrane type MMPs (MT-MMP, ADAM10 and 17) were included in this mechanism.
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