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2012 Fiscal Year Final Research Report

Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation

Research Project

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Project/Area Number 23791679
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

TAKAHASHI Nobunori  名古屋大学, 医学部附属病院, 病院助教 (20570196)

Project Period (FY) 2011 – 2012
Keywords変形性関節症 / ヒアルロン酸 / CD44 / 断片化 / Lipid Raft / Statin製剤
Research Abstract

We demonstrated that simvastatin effectively inhibited the IL-1/OSM induced CD44 cleavage. This inhibitory effect would mainly depend on the suppressive cholesterol production, the major component of lipid raft. However, our current results also suggest that the Ras and Rac/Rho pathway were included in the mechanism of the suppressive CD44 cleavage. The interactional expression of membrane type MMPs (MT-MMP, ADAM10 and 17) were included in this mechanism.

  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] スタチンは軟骨様細胞における CD44 の断片化を阻害する2013

    • Author(s)
      寺部健哉、高橋伸典、小嶋俊久、石黒直樹
    • Organizer
      第26回日本軟骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      20130301-02
  • [Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocyte cells2013

    • Author(s)
      Terabe K, Kojima T, Takahashi N, Ishiguro N
    • Organizer
      59thannual meeting of Orthopaedic Research Society
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      20130126-29

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Published: 2014-09-25  

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