2012 Fiscal Year Final Research Report
The basic study of the oral cancer stem cell by utilizing single cell cloning method
| Project/Area Number |
23792138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 実験腫瘍学 |
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| Research Abstract |
The effect of the chemotherapy for malignant tumor is known to depend partly on the existence of cancer stem cells. Our aim is to eliminate all cells constituting cancer including cancer stem cells which play a major role in drug resistance and disease recurrence. We established several cell lines which have different chemotolerance phenotype and studied the cause of chemoresistance to cisplatin with focus on that difference. PTP4A1 gene was more expressed in cisplatin resistance cell lines compared to sensitive. PTP4A1 activated AKT activation and inhibited apoptosis induced by treatment of cisplatin.
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