2012 Fiscal Year Final Research Report
Roles of nuclear pore complex and lamina in intestinal tumor formation
| Project/Area Number |
23800077
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
KOJIMA Yasushi 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (30464217)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 核膜孔複合体 / 核ラミナ / 大腸がん |
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| Research Abstract |
Recent reports have suggested that Nup88, a component of nuclear pore complex, and Lamin A, a major component of nuclear lamina are overexpressed during intestinal tumorigenesis. I analyzed functional relationships between Wnt signal pathway and expression of Nup88 and Lamin A/C. I found little evidence supporting roles of Wnt signaling in Nup 88 and Lamin A/C expression during intestinal tumorigenesis.
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