2012 Fiscal Year Final Research Report
Roles of nuclear pore complex and lamina in intestinal tumor formation
Project/Area Number |
23800077
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Tumor biology
|
Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
KOJIMA Yasushi 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (30464217)
|
Project Period (FY) |
2011 – 2012
|
Keywords | 核膜孔複合体 / 核ラミナ / 大腸がん |
Research Abstract |
Recent reports have suggested that Nup88, a component of nuclear pore complex, and Lamin A, a major component of nuclear lamina are overexpressed during intestinal tumorigenesis. I analyzed functional relationships between Wnt signal pathway and expression of Nup88 and Lamin A/C. I found little evidence supporting roles of Wnt signaling in Nup 88 and Lamin A/C expression during intestinal tumorigenesis.
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Research Products
(1 results)