Analysis of the effect of oxidative stress on abnormal placentation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890101
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: MIMURA Kazuya 大阪大学, 医学系研究科, 助教 (50437422)
• Project Period (FY): 2011 – 2012
• Keywords: 胎盤形成 / 前置胎盤 / 酸化ストレス / チオレドキシン

Research Abstract

We assesed the expression of trophoblast invasion related molecules in placenta previa, especially accreta. We immunohistochemically assessed the expressions of thioredoxin (TRX), TLR3, TLR4, CD56, CD68, VEGF in the placenta of control, PIH, placenta previa and placenta accreta, and placental bed of control and placenta accreta. TRX expression is slightly higher in PIH placenta, especially chorion and decidua. In placenta previa and accreta, TRX expression is hardly seen in all the area of placenta.There are little differences of expression in other molecules. TRX expression decreased in placenta previa and accreta. It may indicate that oxidative stress decreases andtherefore preeclampsia frequency is reduced in placenta previa.

Research Products

• [Journal Article] Maternal arterial stiffness in normotensive pregnant women who subsequently deliver babies that are small for gestational age (2013)
  • Author(s): Tomimatsu T, Fujime M, Kanayama T, Mimura K, Koyama S, Kanagawa T, Kimura T.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol
  • DOI: doi:10.1016/j.ejogrb.2013.01.016
  • Peer Reviewed
• [Journal Article] Hypoxic preconditioning increasestriiodothyronine (T3) level in the developing rat brain (2013)
  • Author(s): Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T
  • Journal Title: Brain Res
  • DOI: doi:10.1016/j.brainres.2013.01.036
  • Peer Reviewed
• [Journal Article] Maternal carbon dioxide level during labor and its possible effect on fetal cerebral oxygenation: mini review. (2013)
  • Author(s): Tomimatsu T, Kakigano A, Mimura K, Kanayama T, Koyama S, Fujita S, Taniguchi Y, Kanagawa T, Kimura T
  • Journal Title: J Obstet Gynaecol Res Volume: 39(1) Pages: 1-6
  • DOI: doi:10.1111/j.1447-0756.2012.01944.x
  • Peer Reviewed
• [Journal Article] Maternal hyperventilation during labor revisited: its effects on fetal oxygenation. (2012)
  • Author(s): Tomimatsu T, Kakigano A, Mimura K, Kanayama T, Koyama S, Fujita S, Taniguchi Y, Kanagawa T, Kimura T
  • Journal Title: Reprod Sci Volume: 19(11) Pages: 1169-74
  • DOI: doi:10.1177/1933719112443881
  • Peer Reviewed
• [Journal Article] Annexin A2 in amniotic fluid: correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery. (2012)
  • Author(s): Namba F, Ina S, Kitajima H, Yoshio H, Mimura K, Saito S, Yanagihara I
  • Journal Title: J Obstet Gynaecol Res Volume: 38(1) Pages: 137-44
  • DOI: doi:10.1111/j.1447-0756.2011.01651.x
  • Peer Reviewed
• [Journal Article] Ceftriaxone preconditioning confers neuroprotection in neonatal rats through glutamate transporter 1 upregulation (2011)
  • Author(s): Mimura K, Tomimatsu T, Minato K, Jugder O, Kinugasa-Taniguchi Y, Kanagawa T, Nozaki M, Yanagihara I, Kimura T
  • Journal Title: Reprod Sci Volume: 18(12) Pages: 1193-201
  • DOI: doi:10.1177/1933719111410710
  • Peer Reviewed
• [Journal Article] The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary (2011)
  • Author(s): Mabuchi S, Hisamatsu T, Kawase C, Hayashi M, Sawada K, Mimura K, Takahashi K, Takahashi T, Kurachi H, Kimura T.
  • Journal Title: Clin Cancer Res Volume: 17(13) Pages: 4462-73
  • DOI: doi:10.1158/1078-0432.CCR-10-2987
  • Peer Reviewed
• [Journal Article] Silica and titanium dioxide nanoparticles cause pregnancy complications in mice (2011)
  • Author(s): Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M,Yoshida T, Ogura T, Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, Tsunoda S, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsum
  • Journal Title: Nat Nanotechnol Volume: 6(5) Pages: 321-8
  • DOI: doi:10.1038/nnano.2011.41
  • Peer Reviewed
• [Journal Article] Normalisation of angiogenic imbalance after intrauterine transfusion for mirror syndrome caused by parvovirus B19
  • Author(s): Goa S, Mimura K, Kakigano A, TomimatsuT, Kinugasa-Taniguchi Y, Endo M, Kanagawa T, Kimura T.
  • Journal Title: Fetal Diagn Ther Volume: (in press)
  • DOI: doi:10.1159/000348778
  • Peer Reviewed
• [Journal Article] Imbalance of angiogenic factors and characteristic finding of placenta which showed avascular edematous cystic villi in trisomy 13 pregnancy: a case report
  • Author(s): Kakigano A, Mimura K, Kanagawa T, Nakayama M, Kanayama T, Fujita S, Kinugasa-Taniguchi Y, Endo M, Tomimatsu T, Kimura T
  • Journal Title: Placenta Volume: (Placenta)
  • DOI: doi:10.1016/j.placenta.2013.04.001
  • Peer Reviewed
• [Presentation] 卵管間質部妊娠の 1 例と、間質部妊娠との鑑別を要した双角子宮妊娠の 1 例 (2012)
  • Author(s): 味村和哉、金川武司、谷口友基子、金山智子、 柿ヶ野藍子、 藤田聡子、 冨松拓治、木村正
  • Organizer: 第48回日本周産期・新生児医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉)
  • Year and Date: 20120708-10
• [Presentation] パルボウイルス B19 感染により Mirror 症候群を発症した1 例 (2012)
  • Author(s): 味村和哉、金川武司、後安聡子、柿ヶ野藍子、 金山智子、 藤田聡子、 谷口友基子、冨松拓治、木村 正
  • Organizer: 第85回日本超音波医学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 20120525-27
• [Presentation] Placental Features of Chorioamnionitis Colonized With Ureaplasma Species in PretermDelivery (2011)
  • Author(s): Mimura K
  • Organizer: Joint Congress of The 5th Meeting of the Asian Organization for Mycoplasmology (AOM) and The 38th Meeting of the Japanese Society of Mycoplasmology (JSM)
  • Place of Presentation: 長崎県医師会事務局(長崎)
  • Year and Date: 2011-10-20
• [Presentation] ナノシリカの妊娠マウス投与が胎盤に与える影響 (2011)
  • Author(s): 味村和哉、野崎昌俊、柳原格
  • Organizer: 第47回日本周産期・新生児医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-11