Expression of PRL-3 and its clinicopathologic significance in oral squamous cell carcinoma

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890125
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: YOSHIDA Shoko 岡山大学, 岡山大学病院, 医員 (00616047)
• Project Period (FY): 2011 – 2012
• Keywords: PRL-3 / 口腔扁平上皮癌

Research Abstract

Protein phosphatase of regenerating liver-3 (PRL-3) expressions were significantly higher in oral squamous cell carcinoma and oral epithelial dysplasia than in normal mucosa. PRL-3 expression were correlated with histological differentiation and histological grading of mode of invasion. PRL-3 expression was increased in squamous cell carcinoma and epithelial dysplasia in rat tongue carcinogenesis by 4-nitroquinoline 1-oxide. Our results suggest that PRL-3 plays a key role in tumorigenesis and it may be a novel marker of oral cancer progression.

Research Products

• [Journal Article] Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues (2011)
  • Author(s): Hassan NM, Hamada J, Kameyama T, Tada M, Nakagawa K, Yo sh id a S, Kashiwazaki H, Yamazaki Y, Suzuki Y, Sasaki A, Nagatsuka H, Inoue N, Moriuchi T
  • Volume: 12
  • Pages: 947-51
  • Peer Reviewed
• [Presentation] Expression of cytokeratin in development, invasion and metastasis of oral squamous cell carcinoma (2012)
  • Author(s): Yo sh id a S, Kishimoto K, HASSAN NMM, Domae S,Yoshioka N, Sasaki A
  • Organizer: 21 Congress of the European Association for Cranio-Maxillo- Facial Surgery
  • Place of Presentation: Dubrovnik(Croatia)
  • Year and Date: 20120911-15