2016 Fiscal Year Final Research Report
Control and elucidation of gene expression at a molecular level
| Project/Area Number |
24225005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
板東 俊和 京都大学, 理学(系)研究科(研究院), 准教授 (20345284)
遠藤 政幸 京都大学, 学内共同利用施設等, 准教授 (70335389)
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| Co-Investigator(Renkei-kenkyūsha) |
ARIVAZHAGAN RAJENDRAN 京都大学, 大学院理学研究科, 研究員 (90723122)
Suzuki Yuki 京都大学, 大学院理学研究科, 研究員 (50636066)
NAMASIVAYAN Ganesh Pandian 京都大学, 物質-細胞統合システム拠点, 特定研究員 (20625446)
SATO Shinsuke 京都大学, 大学院理学研究科, 特定職員
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| Research Collaborator |
HIDAKA Kumi
EMURA Tomoko
HASHIYA Kaori
Taylor Rhys D.
KAWAMOTO Yusuke
ASAMITSU Sefan
TANIGUCHI Junichi
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| Project Period (FY) |
2012-05-31 – 2017-03-31
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| Keywords | 遺伝子発現制御 / エピジェネティックス / 細胞初期化 / Py-Imポリアミド / DNAナノ構造体 |
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| Outline of Final Research Achievements |
The regulating methodologies of epigenetic gene expression were developed by using functional Py-Im polyamide conjugates in our laboratory. In addition, dynamic motions for one molecule level were directly visualized by using DNA frame technologies with atomic force microscope (AFM). By the combination with these chemical biology researches,we would realize to elucidate the mechanism of specific gene expression through the chemical approach based on DNA structures and functions.
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| Free Research Field |
ケミカルバイオロジー、生物有機化学、DNA構造機能解析
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