Development of bone-inducing artificial bone

2015 Fiscal Year Final Research Report

• Project/Area Number: 24240069
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: Chung Ung-il 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
• Co-Investigator(Kenkyū-buntansha): OHBA Shinsuke 東京大学, 大学院工学系研究科, 准教授 (20466733) ; SAKAI Takamasa 東京大学, 大学院工学系研究科, 准教授 (70456151)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 生体材料 / トランスレーショナルリサーチ / 人工骨

Outline of Final Research Achievements

In order to treat bone defect and deformity, we need to use artificial bone. We attempted to enhance its performance by clarifying signaling network for bone formation and integrating it with artificial bone. As a result, we succeeded in differentiating pluripotent stem cell into osteoblastic cells in vitro using 4 small-molecule compounds without using serum, protein or gene. By loading these compounds onto artificial bone and controlling their release, we also succeeded in treating bone defect model in animals within a short period.

Free Research Field

バイオマテリアル工学