Functional analysis of tumor suppressor genes by generating gene-modified mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 24240120
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyushu University
• Principal Investigator: Suzuki Akira 九州大学, 生体防御医学研究所, 教授 (10311565)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: Hippo / MOB1 / YAP / TAZ / p53 / PTEN / がん抑制遺伝子

Outline of Final Research Achievements

Most of the cancer patients still show bad prognosis, in spite of the tremendous progress of Molecular Biology. Therefore, new molecular targeting drugs are awaited. Functions of cancer suppressor genes should urgently be studied, because they will become the nice targets for the cancer treatment. Among the cancer suppressor genes, p53, PTEN, and Hippo signaling pathways are the most important for the onset of cancers, because these genes are frequently altered in a variety of cancers, and they can cause various cancers by single gene alteration, as oncogenic drivers. We clarified the functions of these cancer suppressor genes by making full use of these gene-altered mice, the tumor spectrum by Hippo pathway alteration, and Hippo pathway-targeted anti-cancer drugs.

Free Research Field

腫瘍学・生化学