Function of cell adhesion on protein-adsorbed well-defined nanostructured interface

2016 Fiscal Year Final Research Report

• Project/Area Number: 24241042
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: The University of Tokyo
• Principal Investigator: Takai Madoka 東京大学, 大学院工学系研究科(工学部), 教授 (40287975)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ナノ相分離 / ブロックコポリマー / タンパク質 / 細胞 / 界面

Outline of Final Research Achievements

In order to create suitable biocompatible materials for various tissue engineering applications, it is important to be able to understand protein adsorption and cell adhesion behaviours on the material surfaces. It is known that the nanoscale distribution of adhesive ligands affects cell adhesion behaviours. However, how nanoscale distribution of adsorbed proteins affect cell adhesion behaviours is still unclear. Therefore, in this study, we investigate the effect of the distribution of adsorbed proteins by the phase reversal of amphiphilic block copolymers composed of protein-adsorptive and non-adsorptive on cell adhesion behaviors. The difference of cell adhesion behaviours between opposite nano phase structures may be caused by the distributions of adsorbed proteins. It was concluded that in addition to the density of adsorbed proteins, the distribution also greatly affects cell adhesion.

Free Research Field

界面工学