Molecular characterization of Colitis Associated Cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24249046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: HIBI Toshifumi 慶應義塾大学, 医学部, 名誉教授 (50129623)
• Co-Investigator(Kenkyū-buntansha): HARUHIKO Ogata 慶應義塾大学, 医学部, 教授 (30177117) ; TAKANORI Kanai 慶應義塾大学, 医学部, 教授 (40245478) ; TOSHIRO Sato 慶應義塾大学, 医学部, 特任准教授 (70365245)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下部消化管学

Outline of Final Research Achievements

Inflammatory bowel disease is characterized by chronic mucosal inflammation and the number of patients are increasing in our country. Duration of disease is positively correlated to the occurrence of colorectal cancer, which is referred to as Colitis associated cancer (CAC). CAC exhibit different clinical features and therapeutic response in comparison to sporadic colorectal cancer. To elucidate carcinogenic mechanism for CAC, we attempted to establish organoids from CAC. We established 6 CAC organoids and performed gene expression microarray analysis, exome analysis and copy number variation analysis. We observed less frequent mutations in APC and higher prevalence of TP53 mutations in CAC as compared to sporadic colorectal cancer. The established CAC organoids and their molecular characterization data can be useful resource for basic and translational research for CAC.

Free Research Field

医歯薬学