2014 Fiscal Year Final Research Report
Development of neuroprotective treatment for incurable ocular diseases
| Project/Area Number |
24249082
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Ohashi Hanako 京都大学, 医学部附属病院, 准教授 (20372162)
KAKIZUKA Akira 京都大学, 大学院生命科学研究科, 教授 (80204329)
IMAMURA Hiromi 京都大学, 白眉センター, 特定准教授 (20422545)
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| Project Period (FY) |
2012-10-31 – 2015-03-31
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| Keywords | 神経保護 / 眼難治疾患 |
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| Outline of Final Research Achievements |
We have examined neuroprotective effects of inhibitors for ATP activity of VCP on glaucoma and retinal degeneration animal models. The inhibitors suppressed decrease of the retinal ganglion cells and thinning of the retinal nerve fiber layer in NMDA-induced acute injury model, DBA2J, and GLAST knockout mice. The inhibitors suppressed decrease of photoreceptor cells and worsening of vusual function in rd10, rd12 mice and model rabbits of retinitis pigmentosa. The VCP ATPase inhibitors might protect neural cells by reducing decrease of ATP and ER stress in the cells.
The VCP ATPase inhibitors may be a new treatment for ocular diseases.
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| Free Research Field |
眼科学
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