Genomic epideological study of age-related macular degenration to develop individualized medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24249083
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyushu University
• Principal Investigator: TATSURO Ishibashi 九州大学, 医学(系)研究科(研究院), 教授 (30150428)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Shigeo 福岡大学, 医学部, 講師 (50363370) ; ENAIDA Hiroshi 佐賀大学, 医学部, 教授 (00363333) ; IKEDA Yasuhiro 九州大学, 大学病院, 助教 (20380389) ; KUBO Michiaki 独立行政法人理化学研究所, その他部局等, その他 (30442958)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 加齢黄斑変性 / 遺伝子多型 / 治療反応性

Outline of Final Research Achievements

TNFRSF10A was consistently expressed in retinal pigment epithelial cells in human retina. We demonstrated that the susceptible allele of rs13278062 decreased TNFRSF10A expression in mRNA and protein level. We also identified the anti-oxidative role of TNFRSF10A in the pathogenesis of age-related macular degeneration (AMD). We assessed risk scores by combining genetic and environmental factors, which could be useful for predicting development of AMD. We identified 4 SNPs which could associate with response to anti-VEGF therapy in the patients with exudative AMD. This study can facilitate an establishment of preventive and personalized medicine in AMD based on genomic information.

Free Research Field

眼科学