Environmental and Genetic risk factors of Atopic dermatitis among 7-year old children in birth cohort

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390152
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hokkaido University
• Principal Investigator: ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
• Co-Investigator(Kenkyū-buntansha): NOMURA Toshifumi 北海道大学, 大学院医学研究科, 助教 (50399911) ; KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449) ; SHIMIZU Hiroshi 北海道大学, 大学院医学研究科, 教授 (00146672)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Seiko 北海道大学, 大学院医学研究科, 助教 (30448831)
• Research Collaborator: AIT BAMAI Yu ; TAJIMA Shuji ; UKAWA Shigekazu ; CONG Shi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 環境 / アレルギー・喘息 / アトピー性皮膚炎 / 衛生 / 遺伝子

Outline of Final Research Achievements

The present study examined the risk of environmental factors such as mite allergens, phthalates, and organophosphate in house dust and filaggrin (FLG) gene variants on atopic dermatitis (AD) among 7 years old children who are participating in the Hokkaido study on Environment and Children's Health. About 10% of the participants in this study had FLG gene variants, which was consistent with other previous studies. The children with FLG gene variants significantly increased the risk of AD at 2 and 4 years of age, but were not at 7 years of age. Among 7 years old children with high levels of DiNP and without FLG gene variants significantly increased the risk of AD.

Free Research Field

公衆衛生学