Molecular clarification of trans-differentiation to brown adipocytes through the action of soluble receptor LR11

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390231
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Toho University (2013-2014); Chiba University (2012)
• Principal Investigator: BUJO Hideaki 東邦大学, 医学部, 教授 (80291300)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: LR11 / 脂肪細胞 / 褐色 / エネルギー産生 / トランスディファレンシエーション / 糖尿病 / 可溶性

Outline of Final Research Achievements

The aim of study is to clarify the physiological significance of and molecular mechanism underlying the trans-differentiation of brown from white adipocytes in LR11-deficent mice, together with the analyses of LR11-overexpressing hematological cells and LR11-decreasing neuronal tissues. Our findings demonstrate that the soluble form of LR11 (sLR11) suppresses thermogenesis in adipose tissue in a cell autonomous manner. Mice lacking LR11 were protected from diet-induced obesity due to increased browning of white adipose tissue and hyper-metabolism. In addition, the shedding of LR11 is regulated by proteinase with other molecules, and the soluble form and the left intracellular form may function as independent molecules for the regulation of cell phenotype. Thus, the regulation of slR11 production is expected as a novel target for developing strategies to treat obesity and diabetes.

Free Research Field

代謝学