Reguratory mechanisms of radiation sensitivity by molecules expressed in epigenetics-dependent manners

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390289
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: MIYAGAWA Kiyoshi 東京大学, 医学(系)研究科(研究院), 教授 (40200133)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線治療生物学 / エピジェネティクス

Outline of Final Research Achievements

To explore the possibility that molecules expressed in somatic cells in epigenetics-dependent manners affect the machinery responding to DNA damage induced by radiation and others, we investigated roles of meiosis-specific molecules in somatic cells. Our studies revealed that the meiosis-specific protein SYCE1 is expressed in some types of cancers and induces tolerance to radiation by promoting DNA double-strand break repair mediated by homologous recombinational repair and by nonhomologous end-joining through activation of the genome damage response.

Free Research Field

医学