2014 Fiscal Year Final Research Report
Reguratory mechanisms of radiation sensitivity by molecules expressed in epigenetics-dependent manners
Project/Area Number |
24390289
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | The University of Tokyo |
Principal Investigator |
MIYAGAWA Kiyoshi 東京大学, 医学(系)研究科(研究院), 教授 (40200133)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 放射線治療生物学 / エピジェネティクス |
Outline of Final Research Achievements |
To explore the possibility that molecules expressed in somatic cells in epigenetics-dependent manners affect the machinery responding to DNA damage induced by radiation and others, we investigated roles of meiosis-specific molecules in somatic cells. Our studies revealed that the meiosis-specific protein SYCE1 is expressed in some types of cancers and induces tolerance to radiation by promoting DNA double-strand break repair mediated by homologous recombinational repair and by nonhomologous end-joining through activation of the genome damage response.
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Free Research Field |
医学
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