Relationship between onset of T cell leukemia and immunodeficiency in young age in a mouse model of adult T-cell leukemia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Rakuno Gakuen University (2014); Kumamoto University (2012-2013)
• Principal Investigator: OHSUGI Takeo 酪農学園大学, 獣医学群, 教授 (00211102)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: HTLV-1 / animal model / mice / immunodeficiency

Outline of Final Research Achievements

Transgenic (Tg) mice expressing Tax, a human T-cell leukemia virus type 1 (HTLV-1) developed a mature T-cell leukemia similar to adult T-cell leukemia. While expanding the Tax-Tg mouse colony, we found several mice within 6 months of ages developed infectious dermatitis. These mice could not eliminate the inoculated bacteria in the skin. In addition, Treg cells (CD4+CD25+Foxp3+) counts were increased in these mice. Thus, the mice are considered to be an immunodeficiency state. Next, we investigated to compare the incidence of T cell leukemia between immunodeficiency and normal mice possessed the possibility of elimination of inoculated bacteria in Tax-Tg mice. There was no significant difference for leukemia onset in the two mouse groups.

Free Research Field

実験動物学