The investigation of the interaction between insulin sensitivity and fatty acids

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyorin University (2014); Saitama Medical University (2012-2013)
• Principal Investigator: TOSHIO Hosaka 杏林大学, 医学部, 講師 (60403698)
• Research Collaborator: SAKAUE Hiroshi 徳島大学大学院, 栄養生命学教育部, 教授 (60372645)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: glut4 / トランスロケーション / 細胞骨格 / 脂肪酸

Outline of Final Research Achievements

Insulin stimulates GLUT4 vesicle recruitment from its intracellular storage site to the PM. Cysteine string protein 1 (CSP1) is a SNARE-binding protein involved in the vesicular trafficking of neurotransmitters and other exocytic processes. In this study, we found that CSP1 is involved in insulin resistance by interrupting GLUT4 vesicle docking with the PM.
The fatty acid binding protein X has reported to bind CSP1. The down-regulation of fatty acid binding protein X increases the CSP1 expression and decrease the insulin stimulated GLUT4 translocation. We are now investigating and confirming the preliminary result about the role of the fatty acid binding protein X in GLUT4 translocation and diabetes to exam the interaction with specific fatty acid and cytoskeleton and analyze the knockout mice, belonging to find the new targets of diabetes treatment.

Free Research Field

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