Effects of the mixture of an oral nutritional product and health food material on inflammatory bowel disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Fujita Health University
• Principal Investigator: CHIHARA Takeshi 藤田保健衛生大学, 藤田記念七栗研究所, 講師 (00217241)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIGUCHI Takashi 藤田保健衛生大学, 医学部, 教授 (40198974) ; ITO Akihiro 藤田保健衛生大学, 医学部, 准教授 (50273355) ; SHIMPO Hiroshi 藤田保健衛生大学, 藤田記念七栗研究所, 教授 (10142580)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: デキストラン硫酸ナトリウム / 潰瘍性大腸炎 / GFO混合物 / 高温高圧処理ニンニク

Outline of Final Research Achievements

Ulcerative colitis is an important risk factor for colon cancer. Therefore, its prevention and symptom improvement are key factors for decreasing colon cancer rates. We previously reported the effects of the oral administration of a three-component mixture (GFO) containing glutamine (G), soluble fiber (F), and oligosaccharide (O) with the same constituents of the oral nutritional product GFO in a dextran sulfate sodium-induced ulcerative colitis mouse model, and indicated that the underlying mechanism involved colonic mucosal protection.We herein investigated the effects of the simultaneous administration of GFO and high temperature and pressure-treated garlic (GFO-H) as a health food material, which may inhibit the secretion of inflammatory cytokines. As a result, GFO-H prevented the length of the colon from being shortened; however, it did not show additive effects, indicating the necessity of examining methods to appropriately administer it.

Free Research Field

生化学