2014 Fiscal Year Final Research Report
Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.
| Project/Area Number |
24590331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAYAMA Takashi 順天堂大学, 医学部, 准教授 (10230012)
MORIMOTO Sachio 九州大学, 医学部, 准教授 (50202362)
NAKAZATO Yuji 順天堂大学, 医学部, 教授 (30266035)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リアノジン受容体 / 不整脈 / カルシウム / カテコラミン誘発性多型性心室頻拍 / 抗不整脈薬 |
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| Outline of Final Research Achievements |
The agents acting on type 2 ryanodine receptor (RyR2) are expected to be good anti-arrhythmic and/or preventive drugs. In this study, we developed experimental systems that are useful for search of anti-arrhythmic drugs acting on RyR2; one is arrhythmogenic myocardium and the other is a cultured cell system expressing recombinant RyR2 molecules.
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| Free Research Field |
薬理学
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