2014 Fiscal Year Final Research Report
A strategy of RAGE shedding is promising for conquering diabetic vascular complications
| Project/Area Number |
24590375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiroshi 金沢大学, その他部局等, 理事 (00115198)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | RAGE / 可溶型RAGE / shediing |
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| Outline of Final Research Achievements |
Receptor for advanced glycation end-products (RAGE) is considered linked to the onset and progression of diabetic vascular complications and atherosclerosis. By focusing on target therapies against RAGE, one potentially useful strategy is the conversion of the membrane-bound form of RAGE (mRAGE) to soluble isoform (sRAGE). The ectodomain shedding can increase the sRAGE level and concomitantly decrease mRAGE expression, potentially leading to the prevention and the attenuation of the diabetic vascular diseases. In this study, we screened drug and chemical libraries and identified useful candidates to mediate the ectodomain shedding of RAGE. Our finding will provide promising drugs for treating diabetic patients.
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| Free Research Field |
生化学
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