Genomic loci analysis associated with prostate cancer susceptibility using a genome-wide association study for the pathological diagnosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kochi University
• Principal Investigator: FURIHATA Mutsuo 高知大学, 教育研究部医療学系, 教授 (10209158)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺癌 / がん感受性遺伝子座 / ゲノムワイド関連解析 / SNP / 免疫組織化学

Outline of Final Research Achievements

We performed a genome-wide association study (GWAS) of multiple loci associated with prostate cancer susceptibility in a Japanese population and identified additional three new loci reached genome-wide significance on chromosomes 11q12, 10q26 and 3p11.2. We also identified that IRX4 (Iroquois homeobox 4) is a causative gene of the PC susceptibility locus at 5p15. Knockdown of IRX4 in prostate cancer cells enhanced their growth and IRX4 overexpression suppressed their growth, indicating the functional association of IRX4 with PC and its tumor suppressive effect. In prostate cancer diagnosis, neurotransmitter polypeptide neuropeptide-Y (NPY) had a potential as a prostate cancer biomarker polypeptide. We also found Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibited growth and angiogenesis of prostate cancer in vitro and in vivo.

Free Research Field

基礎医学・人体病理学