Evaluation of stanniocalcin-1 and NADPH oxidase as marker of metastasis in breast cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590700
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: TANAKA MAKI 札幌医科大学, 医学部, 助教 (40207139)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI SATOSHI 札幌医科大学, 医学部, 教授 (30332919) ; KOBAYASHI DAISUKE 札幌医科大学, 医学部, 講師 (50295359) ; WATANABE NAOKI 札幌医科大学, 医学部, 名誉教授 (10158644) ; KURIBAYASHI KAGEAKI 札幌医科大学, 医学部, 講師 (50381257)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: Stanniocalcin-1 / NADPH オキシターゼ / 乳癌 / 転移能 / 浸潤能

Outline of Final Research Achievements

In this study, we aimed to evaluate potential marker of metastasis in breast cancer. Reactive oxygen species, produced from NADPH oxidase (NOX), affect cancer metastasis and accelerate cell migration. Stanniocalcin-1 (STC-1), a regulator of calcium metabolism, is highly expressed in tumor cells. Therefore, we focused our research on calcium-dependent NOX5 and STC-1 molecules. High levels of STC-1 in breast cancer cells accelerated cell motility and enhanced lung metastasis in mice. However, no difference in cell migration was observed with high levels of NOX5. Thus, we conclude that STC-1 enhances the metastatic potential of breast cancer cells and our results suggest that STC-1 may have utility as a novel prediction marker of metastasis.

Free Research Field

臨床検査医学