2014 Fiscal Year Final Research Report
Clarification of molecular pathogenesis of hematological diseases by analyzing functional role of myosin superfamily
| Project/Area Number |
24590703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHIHARA Masaaki 北里大学, 医学部, 教授 (80165084)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血小板 / 細胞骨格 |
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| Outline of Final Research Achievements |
We have shown the findings as follows. 1) myosinVI transferred into the nucleus from cytosol in non-secretion type of myeloma cells. This might be a possible mechanism how non-secretion type myeloma has a poor prognosis. 2) myosin II has an important role on CD3 expression on the plasma membrane and stabilization of immune synapse. 3) Knock-down of myosin IIB is enough to restore megakaryocyte differentiation in AML cells with RUNX1 mutation. 4) The tail mutations hampered the ATP-induced formation of foleded conformation thus stabilizing the myosin aggregates.
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| Free Research Field |
血液学
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