2015 Fiscal Year Final Research Report
Autopsy diagnosis of deaths due to overdoses of insulin: development of detection methods of insulin formulations
| Project/Area Number |
24590873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Kenji 福岡大学, 医学部, 講師 (00090738)
WATERS Brian 福岡大学, 医学部, 助教 (00609480)
KUBO Shin-ichi 福岡大学, 医学部, 教授 (10205122)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | インスリン / GC-MS / LC-MS/MS / 低血糖症 |
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| Outline of Final Research Achievements |
During this study period, meta-cresol, one of the additives in insulin formulations, could be detected with a head space-solid phase micro extraction (HS-SPME) method using gas chromatography-tandem mass spectrometry (GC-MS/MS), and quantitation was believed to be achievable by the application of the method. For insulin analogues, detection was possible using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and quantitation was also considered a possibility.
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| Free Research Field |
法医学
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