Studies on molecular basis of inhibitory effect of surfactant protein A against cytotoxicity of human b-defensin3.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: ARIKI Shigeru 札幌医科大学, 医学部, 講師 (80464478)
• Co-Investigator(Renkei-kenkyūsha): KUROKI Yoshio 札幌医科大学, 医学部, 教授 (70161784)
• Research Collaborator: UEHARA Yasuaki
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 自然免疫 / 抗菌ペプチド / 肺コレクチン

Outline of Final Research Achievements

Antimicrobial peptides are host defense peptides with a broad spectrum of microbicidal activity. In this study, we suggested that combined use of hBD3 and SP-A-derived peptide (SAP01) is a candidate as a therapeutic reagent against infectious diseases. Binding of SAP01 to hBD3 attenuated cytotoxicity and excess inflammation induced by hBD3. Interestingly, SAP01 did not affect microbicidal activity at concentration sufficient for anti-cytotoxic activity. Because hBD3 also effectively kill drug-resistant microbes, there is appreciable interest in hBD3 for pharmaceutical applications.

Free Research Field

生化学