2014 Fiscal Year Final Research Report
Molecular profiling and biomarker study of thoracic malignancies
| Project/Area Number |
24591186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University (2013-2014)
Shizuoka Cancer Center Research Institute (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOH Yasuhiro 和歌山県立医科大学, 医学部, 講師 (80426519)
SERIZAWA Masakuni 静岡県立静岡がんセンター研究所, 新規薬剤開発・評価研究部, 研究員 (00569915)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Haruhiko 杏林大学, 呼吸器・甲状腺外科, 教授 (60399590)
ENDO Masahiro 静岡県立静岡がんセンター, 画像診断科, 部長
NAKAJIMA Takashi 静岡県立静岡がんセンター, 病理診断科, 部長 (20124422)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 遺伝子異常 / バイオバンク |
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| Outline of Final Research Achievements |
In this project, we established a biobank system of specimens from patients with thoracic malignancies. We conducted tumor genotyping study using tissue samples obtained from the biobank to detect 23 hotspot mutations in 9 cancer-related genes. In adenocarcinoma, EGFR mutation was most frequently detected (35.0%) followed by KRAS mutation (8.5%) and ALK translocation (5.0%). On the other hand, in small-cell lung cancer and squamous cell lung cancer, mutation rate was much lower than that in adenocarcinoma, suggesting driver mutations are rarely detected in those histologic types. We also established genotyping platform utilizing next-generation sequencing technologies for more comprehensive mutational analysis.
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| Free Research Field |
臨床腫瘍学
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