The elucidation of interaction between glomerular podocyte and endothelium in glomerular injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KIYOMOTO hideyasu 東北大学, 東北メディカル・メガバンク機構, 教授 (00304585)
• Co-Investigator(Kenkyū-buntansha): MORIWAKI Kumiko 香川大学, 医学部, 助教 (90398040)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糸球体腎炎 / 血栓性微小血管炎 / ポドサイト / 内皮障害 / PAI－1阻害薬

Outline of Final Research Achievements

The loss of interaction between glomerular podocyte and endothelium leads to severe glomerular injuries such as thrombotic micro-angiopathy (TMA) like glomerulonephritis. Both cells affect each other with endocrine and/or paracrine manner beside the glomerulus basement membrane. The lack of cross-talk between cells leads to initiate glomerulonephritis and accelerate the disease condition. There are certain activities of the plasminogen activation inhibitor (PAI-1) around the glomerular podocyte area in clinical thrombi-genesis and inflammatory reaction, which may involve the progression glomerular damages such as TMA. We verified a newly developing PAI-1 inhibitor to examine the effectiveness onto the animal models of glomerulonephritis. The inhibitor of PAI-1 significantly decreased inflammatory changes and ameliorates the progression of renal injury. These findings suggest a small molecule PAI-1 inhibitor represents new therapeutic strategy as anti-inflammatory agents.

Free Research Field

腎臓内科学