Establishment of a diagnosis of hereditary prion disease and the development of new classification and analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591268
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagasaki University
• Principal Investigator: SATOH Katsuya 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (70398147)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: プリオン病 / 遺伝性

Outline of Final Research Achievements

We succeed to amplify a very small amount of abnormal prion protein in in vitro as an epoch-making method of CSF as a diagnostic stool in human prion disease and reported the Real-time QUIC method and got a high evaluation. I collected CSF samples in cooperation with prion disease surveillance Committee.
I analyzed the specimen of all country prion disease cases using the RT-QUIC method which we developed and elevated on biochemical markers which I reported conventionally and aimed at the establishment of the diagnostic method of genetic prion disease and was able to succeed. Furthermore, I aimed at the development of a new therrpy for genetic prion disease disease and discovered the drug that it was with a therapeutic drug candidate now. I am screening it.

Free Research Field

神経内科学