The strategy for elucidation of diabetogenic factors:functional partition and reintegrate

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591346
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kinki University
• Principal Investigator: BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
• Co-Investigator(Kenkyū-buntansha): IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062) ; KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185) ; NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病疾患感受性遺伝子

Outline of Final Research Achievements

Type 2 diabetes are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to type 2 diabetes in humans. In this study, we constructed consomic and congenic strains, in which the NSY-derived diabetogenic region was introgressed onto the genetic background of control mice. We succeeded to localize and characterize the function of diabetogenic region in the NSY.

Free Research Field

糖尿病