2014 Fiscal Year Final Research Report
Elucidation and therapeutic application of the role of matricellular proteins in allergic inflammation
| Project/Area Number |
24591466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUHARA Kenji 佐賀大学, 医学部, 教授 (00270463)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ペリオスチン |
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| Outline of Final Research Achievements |
Periostin, a matricellular protein, plays a critical role in atopic dermatitis. In this study, we aimed to elucidate the function of periostin in the inflammatory signaling by identifyig periostin receptors, and to establish antagonistic anti-periostin monoclonal antibodies as molecularly-targeted drugs. As a result, we identified an integrin-binding domain on the periostin molecule, and found integrin independent cellular binding to periostin. More over, we established several antagonistic anti-periostin antibodies. They promise the therapeutic application of periostin for allergic diseases.
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| Free Research Field |
免疫学
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