Neuronal Cellular Response to Behavioral Stress

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Defense Medical College
• Principal Investigator: NIBUYA Masashi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 (00228256)
• Co-Investigator(Kenkyū-buntansha): TODA Hiroyuki 防衛医科大学校, その他の部局等, 助教 (00610677) ; NOMURA Soichiro 防衛医科大学校, その他の部局等, 教授 (80113091)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: stress / antidepressant / autophagy / depression / neurotrophic factor / PTSD

Outline of Final Research Achievements

Three years research period resulted in four publications. 1) We reported the protective profile of paroxetine belonging to SSRIs on the gastromucosal epithelium. 2) We reported the enhanced autophagy signaling in the rat hippocampus by the electroconculsive sizure treatment. 3) We reported the significantly decreased plasma BDNF and VEGF concentration after the stressful ranger training in the Japan Self Defense Force. 4) We reported the enhanced autophagy signaling in the rat hippocampus by environmentally enriched housing conditions.

Free Research Field

精神医学