Quantitative measurement of the tissue B-10 concentration in the boron neutron capture therapy.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: SHIMOSEGAWA Eku 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (30370258)
• Co-Investigator(Kenkyū-buntansha): KATO Hiroki 大阪大学, 大学院医学系研究科, 講師 (20448054) ; WATABE Hiroshi 東北大学, 学内共同利用施設等, 教授 (40280820) ; ISOHASHI Kayako 大阪大学, 大学院医学系研究科, 助教 (50598604) ; KANAI Yasukazu 大阪大学, 大学院医学系研究科, 助教 (60397643) ; TATSUMI Mitsuaki 大阪大学, 医学部附属病院, 講師 (60397700)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ホウ素中性子捕捉療法 / F-18 FBPA / PET / 腫瘍 / 標準化

Outline of Final Research Achievements

We tested the correlation of F-18 FBPA PET accumulation and B-10 concentrations in normal and the brain tumor model rats and proved that F-18 FBPA PET can estimate the B-10 level of therapeutic dose in boron-neutron capture therapy (BNCT). Also, we evaluated the B-10 concentration of normal organs from dynamic F-18 FBPA PET of the healthy subject and identified organs with the risk about onset of complications after BNCT. Furthermore, we performed F-18 FBPA PET in the cancer bearing patients and demonstrated that tumor / blood ratio was suitable for a standardization index of F-18 FBPA accumulation in the tumor tissue.

Free Research Field

医歯薬学