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2014 Fiscal Year Final Research Report

Quantitative measurement of the tissue B-10 concentration in the boron neutron capture therapy.

Research Project

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Project/Area Number 24591758
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

SHIMOSEGAWA Eku  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (30370258)

Co-Investigator(Kenkyū-buntansha) KATO Hiroki  大阪大学, 大学院医学系研究科, 講師 (20448054)
WATABE Hiroshi  東北大学, 学内共同利用施設等, 教授 (40280820)
ISOHASHI Kayako  大阪大学, 大学院医学系研究科, 助教 (50598604)
KANAI Yasukazu  大阪大学, 大学院医学系研究科, 助教 (60397643)
TATSUMI Mitsuaki  大阪大学, 医学部附属病院, 講師 (60397700)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsホウ素中性子捕捉療法 / F-18 FBPA / PET / 腫瘍 / 標準化
Outline of Final Research Achievements

We tested the correlation of F-18 FBPA PET accumulation and B-10 concentrations in normal and the brain tumor model rats and proved that F-18 FBPA PET can estimate the B-10 level of therapeutic dose in boron-neutron capture therapy (BNCT). Also, we evaluated the B-10 concentration of normal organs from dynamic F-18 FBPA PET of the healthy subject and identified organs with the risk about onset of complications after BNCT. Furthermore, we performed F-18 FBPA PET in the cancer bearing patients and demonstrated that tumor / blood ratio was suitable for a standardization index of F-18 FBPA accumulation in the tumor tissue.

Free Research Field

医歯薬学

URL: 

Published: 2016-06-03  

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