The effect of PPARalpha agonist fibrate on the intimal hyperplasia of autologous jugular vein grafts

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: SUGIMOTO MASAYUKI 名古屋大学, 医学部附属病院, 病院助教 (00447814)
• Co-Investigator(Kenkyū-buntansha): KOMORI Kimihiro 名古屋大学, 大学院医学系研究科, 教授 (40225587) ; SHIBATA Rei 名古屋大学, 大学院医学系研究科, 特任講師 (70343689) ; KODAMA Akio 名古屋大学, 医学部附属病院, 病院助教 (10528748)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 自家静脈グラフト / 血管 / 内膜肥厚 / PPARs

Outline of Final Research Achievements

The purpose of this study is to examine the effect of drugs on intimal hyperplasia. We did not receive the effect of PPARα agonist fibrate, however, dipeptidyl peptidase 4 inhibitors, which are widely used in patients with type 2 diabetes mellitus, inhiibit the intimal hyperplasia of autologous jugular vein grafts. The rabbits were randomly divided into vildagliptin (a potent dipeptidyl peptidase 4 inhibitor) group and , control group. Results: Under fasting conditions, vildagliptin increased the plasma GLP-1 concentration, without affecting plasma glucose. Acetylcholine induced endothelium-dependent relaxation only in the vildagliptin group. Intimal hyperplasia was significantly less in the vildagliptin group than in the controls. Conclusions: Vildagliptin increased the plasma GLP-1 concentration. It also enhanced acetylcholine-induced [Ca2+]i- independent endothelial nitric oxide release and reduced vein graft intimal hyperplasia, independently of any glycemic control action.

Free Research Field

血管外科学