Immunosuppression system by HLA-F - the development of the eliminating system of allo-reactive T cells except for regulatory T cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nara Medical University
• Principal Investigator: OUJI-SAGESHIMA Noriko 奈良県立医科大学, 医学部, 助教 (30398432)
• Co-Investigator(Kenkyū-buntansha): ISHITANI Akiko 奈良県立医科大学, 医学部, 非常勤講師 (40112544)
• Co-Investigator(Renkei-kenkyūsha): ICHINOHE Tatsuo 広島大学, 医学部, 教授 (80314219) ; TAKAHARA Shiro 大阪大学, 医学(系)研究科(研究院), 寄付講座教授 (70179547) ; UEMOTO Shinji 京都大学, 医学(系)研究科(研究院), 教授 (40252449) ; YOSHIDA Katsunori 奈良県立医科大学, 医学部, 教授 (50192422) ; MORII Takeshi 奈良県立医科大学, 医学部, 講師 (70268451)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 移植外科学 / HLA-F / 制御性T細胞

Outline of Final Research Achievements

HLA-F is expressed on the cell surface of activated immune cells except for regulatory T cells. We considered that HLA-F expressing immune cells except for regulatory T cells associated with rejection. To aim the establishment of new immunosuppression system by elimination of HLA-F positive cells, we analyzed the expression of HLA-F on peripheral lymphocyte from patients who received transplantation.
We analyzed 1538 samples from 265 patients who received transplantation including 99 liver transplantation, 114 kidney transplantation and 52 stem cell transplantation. We detected HLA-F positive cells on peripheral lymphocyte from patients who received transplantation, although the HLA-F expression did not associate with rejection. Additionally, we detected HLA-F expression on steady-state B cells. We concluded that it was difficult to establish the new immunosuppression system using by HLA-F expression.

Free Research Field

免疫学