2014 Fiscal Year Final Research Report
The identification of functional role of CD44 in redox status and the application to therapeutic strategy in cancer
| Project/Area Number |
24591912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWATSUKI Masaaki 熊本大学, 医学部附属病院, 非常勤診療医師 (50452777)
BEPPU Toru 熊本大学, 医学部附属病院, 特任教授 (70301372)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | CD44 / xCT / microRNA / CTC / 消化器癌 |
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| Outline of Final Research Achievements |
CD44v-xCT plays a key role in the maintenance of undifferentiated head and neck squamous cell carcinoma (HNSCC) tumors rather than differentiated-type HNSCC tumors, and confers the ability of evasion from oxidative stress in several types of cancer and thereby promotes the lung metastasis. Furthermore, microRNA qRT-PCR array analysis identified miR-328 as one of the microRNAs targeting CD44 in gastric cancer. miR-328-CD44 signaling mediated by chronic inflammation is implicated in gastric cancer development and progression.
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| Free Research Field |
消化器外科学
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