Comprehensive signal analysis of TM4SF and Wnt for inhibiton of lung cancer progression

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591926
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: The Tazuke Kofukai
• Principal Investigator: HUANG Cheng-long 公益財団法人田附興風会, 医学研究所 第1研究部, 研究主幹 (10271511)
• Co-Investigator(Kenkyū-buntansha): SHOJI Tsuyoshi 公益財団法人田附興風会, 医学研究所第1研究部, 主任研究員 (80402840) ; FUKUI Motonari 公益財団法人田附興風会, 医学研究所第12研究部, 部長 (50342697) ; TAKEMURA Masaya 名古屋市立大学, 大学院医学研究科, 助教 (30378707)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌 / プログレッション / TM4SF / Wnt / 遺伝子治療

Outline of Final Research Achievements

Functional analysis was performed regarding induction of TM4SF and inhibition of Wnt, Induction of CD9 and CD82 inhibited cell motility. Wnt2B-inhibiting vector caused inhibition of cell proliferation and induction of apoptosis. However, suppression of Wnt1 or Wnt5A caused only small effect.
Functional analysis regarding CD9-induction plus Wnt2B-inhibition, and CD82-induction plus Wnt2B-inhibition, found that CD9-induction plus Wnt2B-inhibition was most effective combination for inhibition of tumor progression. Selection of cells both with CD9-induction and Wnt2B-inhibition was important for detection of new targets. However, it has not been established.

Free Research Field

胸部外科学